Two guys talking **it - A Gastroenterology and Hepatology podcast
Two gastroenterologists, A/Professor Jonathan Segal and Dr James Haridy, host conversations that break down complex gastroenterology and hepatology topics. The show covers areas such as liver health, gut microbiota, clinical research, and practical clinical pearls. Episodes are educational but informal and occasionally humorous, with guests appearing from time to time. Listeners are invited to send comments and questions via Twitter or the podcast page.
Episodes
#14: Professor Nick Talley: Dyspepsia, Duodenums and the Trouble With "Functional"
Professor Nick Talley has spent 35 years building the field of neurogastroenterology, and he'd like us all to stop saying "functional". He is one of the global top medical researchers, a distinguished Australian gastroenterologist, and educator known for his seminal work on neurogastrointestinal disorders and co-authoring classic clinical examination textbooks.His argument is that the label sends
#13: Jon and James - GLP-1s: From Lizard spit to liver fibrosis
We're back for Season 2, and Jon and James kick things off with one of their favourite topics: Incretin mimetics. The gut is the biggest endocrine organ in the body, and the data in steatotic liver disease is now as good as anything we have in Hepatology for steatotic liver disease.James and Jon cover the basic pharmacology, how to start and titrate these drugs in practice, what to tell patients a
#12: Season 2 Trailer
We're back. After a longer-than-planned hiatus involving life, work, and the general chaos of being two busy clinicians: Two Guys Talking $#it is returning for Season 2.The spark? Jon got stopped in a hospital corridor by a non-gastro colleague who'd been listening to the IBS episode with Alex Ford and had shared it with her neighbour. Turns out the show has fans in unexpected places, and that was
#01: Introduction
Hello world..
Welcome to Two guys talking **it - a podcast designed for gastroenterologists and hepatologists or anyone interested in the field. Each week, join Jon and James as we bring you expert discussions, the latest research, and practical clinical insights amongst a lot of talking **it..
In this episode we briefly introduce the podcast. Bear with us as we try to work this thing out!
Pleas
#10: A/Prof Gianluca Ianiro and Dr Benjamin Mullish - The gut microbiome in health and disease
Today we’re talking bugs, bowels, and breakthroughs with A/Prof Gianluca Ianiro and Dr. Ben Mullish, two microbiome maestros who make poo science strangely fascinating.A/Prof Gianluca Ianiro is an Associate Professor of Gastroenterology at the Università Cattolica del Sacro Cuore in Rome and a Consultant at the Gastroenterology Unit of the Fondazione Policlinico Universitario Agostino Gemelli IRCC
#05: A/Professor Jason Tye-Din - Coeliac Disease unpacked: Diagnosis, treatment and emerging approaches
We very excited about the episode today!We are joined by A/Professor Jason Tye-Din - a leading expert in coeliac disease and immune-mediated gut disorders. He is Coeliac labratory head at the Walter and Eliza Hall Institute of Medical Research, a Mathison Centenary Fellow at the University of Melbourne, and consultant Gastroenterologist at the Royal Melbourne Hospital. His work focuses on the immu
#03: Our best of 2024 in Gastroenterology and Hepatology
Every podcast is incomplete without a 'best of' episode from the previous year. In this episode Jon and James talk about their big learnings / seminal papers / themes of 2024 in Gastroenterology and Hepatology.
We wish we could have included more!
As always, please leave questions/comments either below or on our X (@2guystalkingit).
#02: Immune checkpoint colitis and hepatitis
Episode #02: Checkpoint conversations
In the first full episode, we tackle the rising challenge of managing colitis and hepatitis triggered by immune checkpoint inhibitors. From recognizing these entities to exploring (non) evidence-based management strategies. Join us for a conversation packed with insights, or if you just want to hear Jon try and pronounce 'nomenclature'.
Please leave any questi
#08: Professor Gideon Hirschfield - The Art and Science of PSC and Autoimmune Hepatitis
SummaryDr Gideon Hirschfield is a leading expert in autoimmune liver diseases, including PSC, PBC, and autoimmune hepatitis. He’s helped shape how these conditions are understood and managed around the world, combining cutting-edge research with a real passion for patient care. Today he discusses his work with autoimmune liver diseases, particularly primary sclerosing cholangitis (PSC) and autoimm
#06: ECCO Takeaways with Dr Beatriz Gros
Jon and James welcome Dr Beatriz Gros, a leading expert in inflammatory bowel disease (IBD). They discuss key findings from the recent European Crohn's and Colitis Conference in 2025. Dr. Beatriz Gros (X: @bealoquebea Instagram: @dr.beatrizgros) is a consultant gastroenterologist based in Córdoba, Spain, specializing in inflammatory bowel disease (IBD). She serves as a Consultant Gastroenterologis
#04: Professor Alex Ford - Navigating disorders of gut-brain interaction and IBS
Professor Alex Ford is a renowned researcher in Gastroenterology, specializing in Disorders of Gut-Brain Interaction (DGBIs). Based at the University of Leeds, he has authored numerous high-impact studies on conditions like irritable bowel syndrome (IBS) and functional dyspepsia. With a focus on evidence-based treatments and advancing our understanding of the gut-brain axis, Professor Ford is wide
#09: A/Professor Emma Halmos & Dr CK Yao - Food is Medicine.. or is it?
Today we welcome two world-leading dietitians to talk all things diet in IBD and IBS....A/Prof Emma Halmos is a senior research dietitian at Monash University and the Alfred Hospital. Her scientific achievements have had a major impact in clinical practice nationally and internationally. The most notable was the pivotal feeding study that demonstrated the low FODMAP diet was efficacious in patient
#07: Dr Simon Gabe - Rebuilding the gut: Intestinal rehabilitation
This is a really special episode with an incredible doctor (Jon says "the best clinician I have ever met"). Today we welcome Dr Simon Gabe, an internationally renowned expert in intestinal rehabilitation. Dr Simon Gabe is a consultant in gastroenterology & intestinal rehabilitation at St Mark’s Hospital and chair of the NHS National Reference Centre for Severe Intestinal Failure at St Mark’s.
#11: A/Prof Elliot Tapper - Liver legends, lies and lactulose
Today we had the privilege of talking to a true superstar in the world of Hepatology.Elliot B. Tapper MD is an Associate Professor in the Division of Gastroenterology and Hepatology at the University of Michigan. He is Academic Chief of Hepatology. His primary goal is to empower patients to enjoy a high quality of life. He is an expert in the management of chronic liver disease, performance of cli
